5.30409

TLR8 Agonist, cpd14b

• Sinónimos: TLR8 Agonist, cpd14b, Toll-Like Receptor 8 Agonist
• Fórmula empírica (notación de Hill): C₁₄H₁₈N₂
• Número de CAS: 1607440-08-3
• Peso molecular: 214.31
• UNSPSC Code: 51111800
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 100 mg/mL
• storage temp.: 2-8°C

Descripción

General description

A pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC₅₀ = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).

A pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC₅₀ = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
TLR8

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Kokatla, H. P., et al. 2014, ChemMedChem9, 719.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable