5.04120

Reboxetine Mesylate

• Sinónimos: Reboxetine Mesylate, (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine methanesulfonate, Edronax, Vestra
• Fórmula empírica (notación de Hill): C₁₉H₂₃NO₃ · xCH₄O₃S
• Número de CAS: 98769-84-7
• Peso molecular: 313.39 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• color: white
• solubility: water: 20 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1
• InChI key: CGTZMJIMMUNLQD-STYNFMPRSA-N

Descripción

General description

A potent and selective inhibitor of noradrenalin uptake (K_i values are 1.1, 129 and >10000 nM for rat NET, SERT and DAT, respectively). Displays >1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

Biochem/physiol Actions

Primary Target
Noradrenalin transporter

Target K_i: 1.1, 129 and >10000 nM for rat NET, SERT and DAT respectively

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze 9-20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sacchetti, G., et al. 1999. Br. J. Pharmacol.128, 1332.

Wong, E., et al. 2000. Biol. Psychiatry.47, 818.
Millan, M., et al. 2001. J. Pharmacol. Exp. Ther.298,565.
Owen, J., et al. 2003 Neurosci. Lett.348, 171.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS07,GHS08
• signalword: Danger
• hcodes: H302 - H360D
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Storage Class: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable