78645

Levetiracetam

analytical standard

• Synonym(s): (αS)-α-Ethyl-2-oxo-1-pyrrolidineacetamide, 2(S)-(2-Oxopyrrolidin-1-yl)butyramide
• Empirical Formula (Hill Notation): C₈H₁₄N₂O₂
• CAS Number: 102767-28-2
• Molecular Weight: 170.21
• MDL number: MFCD03265610
• UNSPSC Code: 41116107
• PubChem Substance ID: 329768167
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• Assay: ≥98.0% (HPLC)
• optical activity: [α]/D -90±5°, c = 1 in acetone
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): forensics and toxicology; veterinary
• format: neat
• SMILES string: CC[C@H](N1CCCC1=O)C(N)=O
• InChI: 1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
• InChI key: HPHUVLMMVZITSG-LURJTMIESA-N
• Gene Information: human ... CACNA1B(774) , SV2A(9900)

Description

General description

Levetiracetam is an orally active antiepileptic drug, having a high therapeutic index and potential antiepileptogenic and anticonvulsant effects.

Application

Levetiracetam may be used as a reference standard in the determination of levetiracetam in biological fluid samples using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry (HPLC-ESI-MS/MS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Levetiracetam is a pyrrolidine with antiepileptic activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.

Recommended products

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable