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Sigma-Aldrich

Isoflurane

Synonym(s):

Isoflurane, 1-Chloro-1-(difluoromethoxy)-2,2,2-trifluoroethane, 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether

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About This Item

Empirical Formula (Hill Notation):
C3H2ClF5O
CAS Number:
26675-46-7
Molecular Weight:
184.49
EC Number:
247-897-7
MDL number:
MFCD00066609
UNSPSC Code:
12352100
PubChem Substance ID:
329768352
NACRES:
NA.22

vapor pressure

238 mmHg ( 20 °C)

Quality Level

100

form

liquid

refractive index

n20/D 1.302

bp

48.5 °C

density

1.510 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

FC(F)OC(Cl)C(F)(F)F

InChI

1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H

InChI key

PIWKPBJCKXDKJR-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) , GLRA1(2741) , GLRB(2743) , KCNK10(54207) , KCNK18(338567) , KCNK2(3776) , KCNK3(3777) , KCNK9(51305)

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General description

Isofluraneis a fluorinated methyl ether and isomer of enflurane. The Federal DrugAdministration (FDA) has approved it for use as a volatile anesthetic to induceand maintain general anesthesia.

Application

Isoflurane is a volatile anesthetic agent mainly used to study its interaction with the biological system.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H336

Hazard Classifications

STOT SE 3

Target Organs

Central nervous system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain.
Brambrink AM, et al.
Anesthesiology, 112(4), 834-841 (2010)
Satya Prathyusha Bhamidimarri et al.
Structure (London, England : 1993), 27(2), 268-280 (2018-12-18)
Research efforts to discover potential new antibiotics for Gram-negative bacteria suffer from high attrition rates due to the synergistic action of efflux systems and the limited permeability of the outer membrane (OM). One strategy to overcome the OM permeability barrier
Hao Zhang et al.
Molecular medicine reports, 22(2), 915-925 (2020-07-07)
Dilated cardiomyopathy (DCM) is a primary cardiomyopathy with high mortality. The aim of the present study was to identify the related genes in DCM. The four expression profiles (GSE17800, GSE21610, GSE42955 and GSE79962) downloaded from the Gene Expression Omnibus (GEO)
Wenjuan Sun et al.
Frontiers in pharmacology, 12, 708575-708575 (2021-10-01)
Maslinic acid (MA), also named crategolic acid, is a pentacyclic triterpene extracted from fruits and vegetables. Although various beneficial pharmacological effects of MA have been revealed, its effect on renal fibrosis remains unclear. This study was designed to clarify whether
Joanna Ruth Appel et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(26), 5949-5968 (2018-06-02)
Vacuolar sorting protein 35 (VPS35) is a critical component of retromer, which is essential for selective endosome-to-Golgi retrieval of membrane proteins. VPS35 deficiency is implicated in neurodegenerative disease pathology, including Alzheimer's disease (AD). However, exactly how VPS35 loss promotes AD
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