GRM5
glutamate receptor, metabotropic 5
Synonyms:
GPRC1E, MGLUR5, mGlu5
Species:
Human GRM5 (2915), Mouse Grm5 (108071), Rat Grm5 (24418), chicken GRM5 (373933), cow GRM5 (100336861), domestic cat GRM5 (101091895), dog GRM5 (485146), domestic guinea pig Grm5 (100714109), naked mole-rat Grm5 (101696979)
UniProtKB ID:
Gene ID:
- Human(2915) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
- Mouse(108071) glutamate receptor, metabotropic 5
- Rat(24418) glutamate receptor, metabotropic 5
- chicken(373933) glutamate receptor, metabotropic 5
- cow(100336861) glutamate receptor, metabotropic 5
- domestic cat(101091895) glutamate receptor, metabotropic 5
- dog(485146) glutamate receptor, metabotropic 5
- domestic guinea pig(100714109) glutamate receptor, metabotropic 5
- naked mole-rat(101696979) glutamate receptor, metabotropic 5
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Small Molecule - Agonist
Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor™ 488, from rabbit, ALEXA FLUOR™ 488,
Species Reactivity
bovine, feline, horse, human, mouse, primate, rat
Application
immunocytochemistry
immunofluorescence
immunofluorescence
Anti-mGluR5 Antibody, clone 11D9.1, clone 11D9.1, from mouse,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
western blot
Anti-mGluR5 Antibody, clone N75/33, clone N75/33, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-Metabotropic Glutamate Receptor 5 Antibody, pain, Chemicon®, from rabbit,
Species Reactivity
bovine, feline, horse, human, mouse, primate, rat
Application
immunohistochemistry
western blot
western blot
Anti-GRM5 Antibody, clone 4I1G3, Rabbit Monoclonal, ,
Species Reactivity
mouse, rat
Application
western blot