SAB4501894

Anti-MMP-7 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): MMP-7, Matrilysin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 29 kDa
• species reactivity: human, mouse, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P09237
• UniProt accession no.: P09237
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MMP7(4316)

Description

General description

Anti-MMP-7 Antibody detects endogenous levels of total MMP-7 protein.

Matrix metalloproteinase-7 (MMP7) is also termed as matrilysin. It is located on human chromosome 11q21-->q22. It belongs to the MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.

Immunogen

The antiserum was produced against synthesized peptide derived from human MMP-7.

Immunogen Range: 218-267

Application

Anti-MMP-7, C-Terminal antibody has been used in immunofluorescence.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

Overexpression of matrix metalloproteinase-7 (MMP7) is observed in various cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. It is essential for the development of tumor in the absence of PKP3 (plakophilin3).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable