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Key Documents

SAB3500723

Sigma-Aldrich

Anti-TM4SF1 antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

mol wt

22 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

General description

Transmembrane 4 L6 family member 1 (TM4SF1) is a protein encoded by the TM4SF1 gene in humans. It is a cell surface antigen, which is highly expressed in lung, breast, colon and ovarian carcinomas. The TM4SF1 gene is localized on human chromosome 3q25.1.

Immunogen

Antibody was raised against an 18 amino acid peptide near the amino terminus of human TM4SF1.

Biochem/physiol Actions

Transmembrane 4 L6 family member 1 (TM4SF1) has a novel function in androgen receptor (AR) signaling. Its mRNA expression is higher in prostate cancer tissues as compared to benign prostatic hyperplasia (BPH). It is found to contribute to prostate cancer cell metastasis. The TM4SF1 gene serves as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins. It uniquely initiates the formation of nanopodia and facilitates cell polarization and migration. TM4SF1 also regulates tumor cell motility and invasiveness. It is abundant on the plasma membrane and on intracellular vesicles.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500723.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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he tumour-associated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: implication for tumour cell motility
Journal of Cell Science (2008)
KARE Genomewide Association Study of Blood Pressure
Using Imputed SNPs
Kyung-Won Hong
Genomics & informatics, 103-107 (2010)
TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration
Andrew Zukauskas
Angiogenesis, 14 (2011)
TM4SF1, a novel primary androgen receptor target gene over-expressed in human prostate cancer and involved in cell migration
Prostate, 71 (2011)
Cloning and expression of the tumor-associated antigen L6
J S Marken
Proceedings of the National Academy of Sciences of the USA, 89 (1992)

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