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Key Documents

SAB3500044

Sigma-Aldrich

Anti-AP2M1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AP-2 mu-1, Anti-AP50, Anti-Adaptor-related protein complex 2 mu 1, Anti-CLAPM1, Anti-u2

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AP2M1(1173)

Related Categories

Immunogen

AP2M1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human AP2M1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500044.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.
Neveu G
PLoS Pathogens (2012)
Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint.
Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint.
Aguet F
Developmental Cell (2013)
BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.
Harris JL
PLoS ONE (2013)
Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization.
Shi ZZ
Clinical Cancer Research (2013)

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