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Key Documents

SAB1405747

Sigma-Aldrich

Anti-EGR2 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

AT591, CMT1D, CMT4E, DKFZp686J1957, FLJ14547, KROX20

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~50.3 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

NCBI accession no.

NM_000399.2

UniProt accession no.

P11161

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EGR2(1959)

Related Categories

General description

Early growth response 2 (EGR2) is a zinc finger transcription factor and a member of the EGR family. Structurally, it comprises activation domain(A), DNA binding domain (DBD) zinc finger domain, basic domain (BD) and broadly neutralizing antibody (BNab) interaction domain(R1). The EGR2 gene is mapped to human chromosome 10q21.3.

Immunogen

EGR2 (NP_000390.2, 1 a.a. ~ 476 a.a) full-length human protein.

Sequence
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

Biochem/physiol Actions

Early growth response 2 (EGR2) is essential for peripheral nerve myelination and T cell anergy. It is also needed for the formation of gap junction beta 1 (GJB1) and periaxin along with other myelin proteins. Mutations in the EGR2 gene are implicated in peripheral neuropathies namely Charcot-Marie-Tooth disease type 1 (CMT1), congenital hypomyelinating neuropathy (CHN), and Dejerine-Sottas neuropathy (DSN/CMT). EGR2 upregulation may regulate inflammatory cytokines during recovery from Guillain-Barré syndrome (GBS).

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mutation analysis in the candidate Möbius syndrome genes PGT and GATA2 on chromosome 3 and EGR2 on chromosome 10.
B Van Der Zwaag et al.
Journal of medical genetics, 39(6), E30-E30 (2002-06-19)
Kota Noritsugu et al.
Biochemical and biophysical research communications, 489(4), 455-459 (2017-06-04)
EGR2 is a zinc finger transcription factor that regulates myelination in the peripheral nervous system and T cell anergy. The transcriptional activity of EGR2 is known to be regulated by its co-activators and/or co-repressors. Although the activity of transcription factors
Ernesto Doncel-Pérez et al.
Journal of immunology (Baltimore, Md. : 1950), 196(3), 1102-1107 (2016-01-01)
Guillain-Barré syndrome (GBS) is an immune-mediated peripheral neuropathy. The goal of this research was the identification of biomarkers associated with recovery from GBS. In this study, we compared the transcriptome of PBMCs from a GBS patient and her healthy twin
Roseline Poirier et al.
Frontiers in neuroscience, 2(1), 47-55 (2008-11-05)
The different gene members of the Egr family of transcriptional regulators have often been considered to have related functions in brain, based on their co-expression in many cell-types and structures, the relatively high homology of the translated proteins and their

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