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S5261

Sigma-Aldrich

Sodium selenite

BioReagent, suitable for cell culture, ≥98%

Synonym(s):

Selenious acid, Sodium salt

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About This Item

Linear Formula:
Na2SeO3
CAS Number:
10102-18-8
Molecular Weight:
172.94
EC Number:
233-267-9
MDL number:
MFCD00003489
UNSPSC Code:
12352205
PubChem Substance ID:
24899643
NACRES:
NA.75

biological source

synthetic (inorganic)

Quality Level

200

product line

BioReagent

Assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

>350 °C (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

SMILES string

[Na+].[Na+].[O-][Se]([O-])=O

InChI

1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2

InChI key

BVTBRVFYZUCAKH-UHFFFAOYSA-L

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Application

Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.
This product is cell culture tested (0.005 mg/L) and is appropriate for use in cell culture applications.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Supplementary Hazards

EUH031

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Directed cardiac differentiation of human pluripotent stem cells (hPSCs) enables disease modeling, investigation of human cardiogenesis, as well as large-scale production of cardiomyocytes (CMs) for translational purposes. Multiple CM differentiation protocols have been developed to individually address specific requirements of
Simon P W Hageman et al.
Water research, 47(7), 2118-2128 (2013-03-15)
Removal of the toxic selenium compounds selenite and selenate from waste water before discharge is becoming increasingly imperative in industrialized countries. Bacteria can reduce selenate to selenite, but also further to elemental selenium, selenide or organic selenium. In this paper
Chih-Ching Yang et al.
PloS one, 9(7), e96006-e96006 (2014-07-02)
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