O1877

Ochratoxin A

from Petromyces albertensis, ≥98% (HPLC), powder, mycotoxin

• Synonym(s): N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine
• Empirical Formula (Hill Notation): C₂₀H₁₈ClNO₆
• CAS Number: 303-47-9
• Molecular Weight: 403.81
• Beilstein: 1301486
• MDL number: MFCD00078079
• UNSPSC Code: 12352200
• PubChem Substance ID: 24897954
• NACRES: NA.77

Properties

• product name: Ochratoxin A, from Petromyces albertensis, ≥98% (HPLC)
• biological source: Petromyces albertensis
• Quality Level: 300
• Assay: ≥98% (HPLC)
• form: powder
• impurities: Benzene, free
• solubility: ethanol: soluble
• Mode of action: enzyme | inhibits; protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O
• InChI: 1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
• InChI key: RWQKHEORZBHNRI-BMIGLBTASA-N

Description

Application

Ochratoxin A has been used as a mycotoxin:

• to test its effect on metabolism and hypoxia in human embryonic kidney (HEK293) cells
• to test its cytotoxic effects in bovine mammary epithelial cells
• as a standard for gamma radiation studies with food products and in cytotoxic studies using Hep G2 cells

Biochem/physiol Actions

Ochratoxin A (OTA), a renal toxin, is produced majorly by Aspergillus and Penicillium fungal species. It is immunotoxic, teratogenic myelotoxic, and mutagenic. It effectively interrupts the intestinal barrier functions. OTA displays a long elimination half-life and stimulates the major inflammatory cytokines release.

Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca²⁺ pump activity.

Preparation Note

This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM).

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300,H351
• Precautionary Statements: P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves