K3375

Kynurenic acid

≥98% (HPLC), powder, NMDA receptor antagonist

• Synonym(s): 4-Hydroxyquinoline-2-carboxylic acid
• Empirical Formula (Hill Notation): C₁₀H₇NO₃
• CAS Number: 492-27-3
• Molecular Weight: 189.17
• Beilstein: 147451
• EC Number: 207-751-5
• MDL number: MFCD00006753
• UNSPSC Code: 12352106
• PubChem Substance ID: 24277986
• NACRES: NA.77

Properties

• product name: Kynurenic acid, ≥98%
• Quality Level: 200
• Assay: ≥98%
• form: powder
• mp: 275 °C (dec.) (lit.)
• SMILES string: OC(=O)c1cc(O)c2ccccc2n1
• InChI: 1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
• InChI key: HCZHHEIFKROPDY-UHFFFAOYSA-N
• Gene Information: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143) , GRIA3(2892) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901) , GUCA2A(2980) , GUCA2B(2981) , NGFR(4804) , SLC23A2(9962) ; rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409)

Description

Application

Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells and human primary astrocytes. It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K and induced pluripotent stem cell (iPSC)-derived neurons cells.

Biochem/physiol Actions

Kynurenic acid (KynA) is a non-selective antagonist of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors. It blocks kainic acid neurotoxicity. Kynurenic acid also blocks nicotinic acetylcholine receptors. It is a by-product of tryptophan catabolic pathway. Kynurenic acid is a neuromodulator and controls the levels of glutamate, dopamine, acetylcholine and α-aminobutyric acid (GABA). KynA controls neuroendocrine functions and altered levels of KynA is a potential marker in depression, schizophrenia Alzheimer′s and Huntington′s diseases. Normal levels of KynA in the brain is crucial for the cognitive function.

Features and Benefits

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves