K1639

K-252a

from Nonomuraea longicatena, ≥98% (HPLC)

• Empirical Formula (Hill Notation): C₂₇H₂₁N₃O₅
• CAS Number: 99533-80-9
• Molecular Weight: 467.47
• MDL number: MFCD00161522
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896210
• NACRES: NA.77

Properties

• biological source: Nonomuraea longicatena
• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: solid
• solubility: DMF: 1 mg/mL; DMSO: 1 mg/mL
• antibiotic activity spectrum: viruses
• Mode of action: enzyme | inhibits
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• InChI key: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Gene Information: human ... NTRK1(4914) ; rat ... Prkca(24680)

Description

Application

K-252a has been used:

• as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in rats
• as a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)
• as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly

Biochem/physiol Actions

K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC₅₀ values between 3 and 25nM and the neurotrophin receptor-tropomyosin receptor kinase.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves