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HPA001927

Sigma-Aldrich

Anti-PREX1 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-P-Rex1 protein antibody produced in rabbit, Anti-Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein antibody produced in rabbit, Anti-PtdIns

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

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This Item
HPA001562HPA007308HPA007575
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

General description

P-Rex1 protein is a Rac-GEF, guanine nucleotide exchange factor, for the RHO family of GTPases, connecting Gβγ and phosphatidylinositol 3-kinase signaling to Rac activation. P-Rex1 promotes membrane ruffling and links mTOR signaling to Rac activation of cell migration.
Rabbit polyclonal PREX1 antibody reacts with human phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein.

Immunogen

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein recombinant protein epitope signature tag (PrEST)

Application

Rabbit polyclonal PREX1 antibody is used to tag phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Ptdlns) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Ptdlns) in cell mobilization at the level of Rac activation.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST86391

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

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Heidi C E Welch
Small GTPases, 6(2), 49-70 (2015-05-12)
The P-Rex family are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. They are distinguished from other Rac-GEFs through their synergistic mode of activation by the lipid second messenger phosphatidyl inositol (3,4,5) trisphosphate and the Gβγ subunits of
Jonathan D Marotti et al.
International journal of breast cancer, 2017, 4537532-4537532 (2017-07-13)
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-Rex1) has been implicated in cancer growth, metastasis, and response to phosphatidylinositol 3-kinase (PI3K) inhibitor therapy. The aim of this study was to determine whether P-Rex1 expression differs between primary and metastatic human breast tumors
Ricardo Hernández-García et al.
Vascular pharmacology, 74, 60-72 (2015-10-17)
Rho guanine nucleotide exchange factors (RhoGEFs) integrate cell signaling inputs into morphological and functional responses. However, little is known about the endothelial repertoire of RhoGEFs and their regulation. Thus, we assessed the expression of 81 RhoGEFs (70 homologous to Dbl
Rodolfo Daniel Cervantes-Villagrana et al.
The Journal of biological chemistry, 294(2), 531-546 (2018-11-18)
G protein-coupled receptors stimulate Rho guanine nucleotide exchange factors that promote mammalian cell migration. Rac and Rho GTPases exert opposing effects on cell morphology and are stimulated downstream of Gβγ and Gα12/13 or Gαq, respectively. These Gα subunits might in
Colin R Lindsay et al.
Nature communications, 2, 555-555 (2011-11-24)
Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western

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