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G3798

Sigma-Aldrich

10074-G5

≥98% (HPLC)

Synonym(s):

Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine, N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine, N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine

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About This Item

Empirical Formula (Hill Notation):
C18H12N4O3
CAS Number:
413611-93-5
Molecular Weight:
332.31
MDL number:
MFCD00576774
UNSPSC Code:
12352200
PubChem Substance ID:
329799918
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

red

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

[O-][N+](=O)c1ccc(Nc2ccccc2-c3ccccc3)c4nonc14

InChI

1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H

InChI key

KMJPYSQOCBYMCF-UHFFFAOYSA-N

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1 of 4

This Item
C19627365448.00412
Chloroacetic acid ACS reagent, ≥99.0%

402923

Chloroacetic acid

Chloroacetic acid 99%

C19627

Chloroacetic acid

Chloroacetic acid PESTANAL®, analytical standard

36544

Chloroacetic acid

Chloroacetic acid for synthesis

8.00412

Chloroacetic acid

assay

≥99.0%

assay

99%

assay

98-100% (HPLC)

assay

≥99% (acidimetric)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

form

solid

form

crystals

form

-

form

crystals

solubility

water: soluble 3170 g/L at 10 °C

solubility

water: soluble 3,170 g/L at 10 °C

solubility

-

solubility

>1000 g/L

vapor density

3.26 (vs air)

vapor density

3.26 (vs air)

vapor density

3.26 (vs air)

vapor density

-

Biochem/physiol Actions

10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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    Certificates of Analysis (COA)

    Lot/Batch Number
    114M4615V
    061M4604V
    059K47122
    059K47121
    059K4712

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    Chengsheng Wu et al.
    BMC cancer, 18(1), 361-361 (2018-04-04)
    The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To
    Quan Yang et al.
    Frontiers in immunology, 12, 627072-627072 (2021-03-13)
    The accumulation of myeloid-derived suppressor cells (MDSCs) is one of the major obstacles to achieve an appropriate anti-tumor immune response and successful tumor immunotherapy. MDSCs in tumor-bearing hosts are primarily polymorphonuclear (PMN-MDSCs). However, the mechanisms regulating the development of MDSCs
    Alina Castell et al.
    Scientific reports, 8(1), 10064-10064 (2018-07-04)
    MYC is a key player in tumor development, but unfortunately no specific MYC-targeting drugs are clinically available. MYC is strictly dependent on heterodimerization with MAX for transcription activation. Aiming at targeting this interaction, we identified MYCMI-6 in a cell-based protein
    Udom Lao-On et al.
    Biochimica et biophysica acta. Molecular basis of disease, 1866(3), 165656-165656 (2019-12-25)
    Here we showed that the c-Myc oncogene is responsible for overexpression of pyruvate carboxylase (PC) in highly invasive MDA-MB-231 cells. Pharmacological inhibition of c-Myc activity with 10074-G5 compound, resulted in a marked reduction of PC mRNA and protein, concomitant with
    Huabo Wang et al.
    Oncotarget, 6(18), 15857-15870 (2015-06-04)
    The c-Myc (Myc) oncoprotein is deregulated in a large proportion of diverse human cancers. Considerable effort has therefore been directed at identifying pharmacologic inhibitors as potential anti-neoplastic agents. Three such groups of small molecule inhibitors have been described. The first
    View All Related Papers

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