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D9565

Sigma-Aldrich

β-Defensin 1 human

≥98% (HPLC and SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder (from 10 mM acetic acid)

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About This Item

MDL number:
MFCD01865661
UNSPSC Code:
12352202
NACRES:
NA.32

recombinant

expressed in E. coli

Quality Level

200

Assay

≥98% (HPLC and SDS-PAGE)

form

lyophilized powder (from 10 mM acetic acid)

mol wt

estimated mol wt 3.9 kDa

UniProt accession no.

P60022

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi
viruses

Mode of action

cell wall synthesis | interferes

storage temp.

−20°C

Gene Information

human ... DEFB1(1672)

Amino Acid Sequence

Asp-His-Tyr-Asn-Cys-Val-Ser-Ser-Gly-Gly-Gln-Cys-Leu-Tyr-Ser-Ala-Cys-Pro-Ile-Phe-Thr-Lys-Ile-Gln-Gly-Thr-Cys-Tyr-Arg-Gly-Lys-Ala-Lys-Cys-Cys-Lys [Disulfide bridges 5-34, 12-27, and 17-35]

General description

Chemical structure: peptide

Biochem/physiol Actions

A small cationic peptide which demonstrates anti-microbial activity. Originally isolated from human plasma, this substance is constitutively expressed in mucosal membrane epithelium.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Articles

Antimicrobial Peptides

With bacterial resistance and emerging infectious diseases becoming potential threats to humans, ribosomally synthesized antimicrobial peptides have become a promising focus area in antibiotic research.

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