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320M-1

Sigma-Aldrich

Cytokeratin 20 (Ks20.8) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

Ks20.8, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (320M-14)
vial of 0.5 mL concentrate (320M-15)
bottle of 1.0 mL predilute (320M-17)
vial of 1.0 mL concentrate (320M-16)
bottle of 7.0 mL predilute (320M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:500

isotype

IgG2aκ

control

colon carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT20(54474)

General description

Cytokeratin 20 is a 46-kDa intermediate filament protein that reacts primarily with gastricand intestinal epithelium, urothelium, and Merkel cells. Anti-Cytokeratin 20 is usefulin the identification of specific types of these epithelial cells under normal, hyperplastic,and neoplastic conditions. Cytokeratin 20 has been detected in various adenocarcinomas,including those of the colon and stomach. Merkel cell carcinomas have shown reactivity. Incontrast, carcinomas of the breast are generally non-reactive.

Quality


IVD
IVD
IVD
RUO

Linkage

Cytokeratin 20 Positive Control Slides , Product No. 320S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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A Rullier et al.
The American journal of surgical pathology, 24(6), 870-876 (2000-06-08)
In the liver, the immunostaining of cytokeratins (CK) 7 and 20 has been used to distinguish usual peripheral cholangiocarcinomas (CC) and colorectal carcinoma metastasis (CRM). However, other subtypes of CC are not infrequent and may be particularly difficult to distinguish
T Tot
Cancer, 85(1), 171-177 (1999-01-28)
Metastatic adenocarcinoma in the liver with an unidentified primary tumor site is a common clinical problem. Pathologists often are asked to identify the primary tumor site. The histologic picture itself usually is not helpful, because the histology may be similar
T Tot
Cancer, 92(10), 2727-2732 (2001-12-18)
Immunohistochemistry is a useful method in the differential diagnosis between pleural mesotheliomas and metastatic adenocarcinomas to the pleura. Cytokeratin (CK) 5-6 is one of the most specific mesothelioma-associated antibodies. Cytokeratin 20 and CK7 have been used successfully in studies determining
Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas
Wang NP, Zee S, Zarbo RJ, Bacchi CE, Gown AM
Appl. Immunohistochem., 3, 99-107 (1995)
Sean K Lau et al.
Human pathology, 33(12), 1175-1181 (2003-01-07)
Distinguishing hepatocellular carcinoma (HCC) from cholangiocarcinoma (CC) and metastatic adenocarcinoma (MA) involving the liver can be problematic, often requiring the use of immunohistochemistry to facilitate diagnosis. Hep Par 1, a monoclonal antibody with expression confined primarily to benign and malignant
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