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SMB01360

Sigma-Aldrich

1-MethylpseudoUridine

≥98% (HPLC)

Synonym(s):

1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione, N1-Methylpseudouridine

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About This Item

Empirical Formula (Hill Notation):
C10H14N2O6
CAS Number:
13860-38-3
Molecular Weight:
258.23
MDL number:
MFCD10687017
UNSPSC Code:
41106305
NACRES:
NA.21

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage temp.

2-8°C

InChI

1S/C10H14N2O6/c1-12-2-4(9(16)11-10(12)17)8-7(15)6(14)5(3-13)18-8/h2,5-8,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,8+/m1/s1

InChI key

UVBYMVOUBXYSFV-XUTVFYLZSA-N

General description

A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase Methylpseudouridine to increase their effectiveness. The modified nucleobase helps cloak mRNA vaccines from the immune system, limiting their undesired immune stimulation, and in certain circumstances may also enhance the synthesis of antigens.

Application

Vaccine development

Other Notes

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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