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77500

Supelco

1,10-Phenanthroline monohydrate

for the spectrophotometric determination of Fe, Pd, V, ≥99.0%

Synonym(s):

o-Phenanthroline monohydrate

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About This Item

Empirical Formula (Hill Notation):
C12H8N2 · H2O
CAS Number:
Molecular Weight:
198.22
Beilstein:
4008096
EC Number:
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.21

Quality Level

Assay

≥99.0% (HPLC)
≥99.0% (NT)
≥99.0%

form

crystals

quality

for the spectrophotometric determination of Fe, Pd, V

technique(s)

UV/Vis spectroscopy: suitable
titration: suitable

ign. residue

≤0.05%

mp

100-104 °C (lit.)
99-104 °C

cation traces

Ca: ≤50 mg/kg
Cd: ≤20 mg/kg
Co: ≤20 mg/kg
Cr: ≤20 mg/kg
Cu: ≤20 mg/kg
Fe: ≤20 mg/kg
K: ≤100 mg/kg
Mg: ≤20 mg/kg
Mn: ≤20 mg/kg
Na: ≤100 mg/kg
Ni: ≤20 mg/kg
Pb: ≤20 mg/kg
Zn: ≤20 mg/kg

SMILES string

O.c1cnc2c(c1)ccc3cccnc23

InChI

1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2

InChI key

PPQJCISYYXZCAE-UHFFFAOYSA-N

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General description

1,10-Phenanthroline monohydrate is a chelating agent.

Application

It has been used in preparing 0.1 % phenanthroline solution. In another study, 80μl of 1,10-Phenanthroline monohydrate was used along with nanoparticles to measure iron content using colorimetric assay.3 It may be used in the preparation of [Mn(1,10-phen)2(mal)].2H2O.
When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.

Biochem/physiol Actions

Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.

Pictograms

Skull and crossbonesEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Insights into the mode of action of the anti-Candida activity of 1,10-phenanthroline and its metal chelates.
McCann M
Metal-based drugs, 7(4), 185-193 (2000)
Generation of magnetic nonviral gene transfer agents and magnetofection in vitro.
Mykhaylyk O
Nature Protocols, 2(10), 2391-2411 (2007)
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 15, 585-585 (1970)
W. Sliwa
Heterocycles, 12, 1207-1207 (1979)
A newly developed Fe-doped calcium sulfide nanoparticles with magnetic property for cancer hyperthermia.
Wu, Steven Yueh-Hsiu, Ching-Li Tseng, and Feng-Huei Lin.
Journal of Nanoparticle Research, 12.4, 1173-1185 (2010)

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