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487929-M

Millipore

Nocodazole

InSolution, ≥97%, 50 mM in DMSO, Inhibitor of mammalian cell mitosis via a highly aspecific antimicrotubular activity

Synonym(s):

InSolution Nocodazole, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate, R17934, R17934, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate

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About This Item

Empirical Formula (Hill Notation):
C14H11N3O3S
CAS Number:
Molecular Weight:
301.32
MDL number:
UNSPSC Code:
12352200

Pricing and availability is not currently available.

Quality Level

Assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

storage temp.

−70°C

InChI

1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChI key

KYRVNWMVYQXFEU-UHFFFAOYSA-N

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This Item
487928M1404SML1665
Nocodazole ≥99% (TLC), powder

M1404

Nocodazole

form

liquid

form

solid

form

powder

form

DMSO solution

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

200

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

storage temp.

−70°C

storage temp.

10-30°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

OK to freeze, desiccated (hygroscopic), avoid repeated freeze/thaw cycles, protect from light

storage condition

OK to freeze

storage condition

-

storage condition

-

General description

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd<2 M). The solid form of this compound (Cat. No. 487928) is also available.

Biochem/physiol Actions

Primary Target
Microtubules
Secondary Target
Certain kinases

Warning

Toxicity: Irritant (B)

Physical form

A 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.

Other Notes

Park, H., et al. 2012. Chem. Med. Chem.7, 53.
Bunz, F., et al. 1998. Science282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci.102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Muta. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

188.6 °F - closed cup - (refers to pure substance)

Flash Point(C)

87 °C - closed cup - (refers to pure substance)


Certificates of Analysis (COA)

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