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309795

Sigma-Aldrich

DIDS disodium salt

≥85% (HPLC), solid, anion transport inhibitor, Calbiochem®

Synonym(s):

DIDS, Disodium Salt, 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na

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About This Item

Empirical Formula (Hill Notation):
C16H8N2O6S4 · 2Na
CAS Number:
53005-05-3
Molecular Weight:
498.48
UNSPSC Code:
12352200
NACRES:
NA.77

product name

DIDS, Disodium Salt, Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.

Quality Level

100

Assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

yellow

solubility

water: 0.5%

shipped in

ambient

storage temp.

−20°C

InChI

1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+

InChI key

YSCNMFDFYJUPEF-OWOJBTEDSA-N

General description

Binds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl- uptake (IC50 = 150 nM) in neuroblastoma cells. Has antiulcerous activity.
Binds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl– uptake (IC50 = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Cl- uptake
Product does not compete with ATP.
Reversible: no
Target IC50: 150 nM inhibiting Cl- uptake in neuroblastoma cells

Warning

Toxicity: Irritant (B)

Other Notes

Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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