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233493

Sigma-Aldrich

Coagulation Factor α-XIIa, Human Plasma

Coagulation Factor α-XIIa, Human Plasma, is a native coagulation factor α-XIIa prepared from homogeneous Factor XII using dextran sulfate. Dextran sulfate is removed after activation.

Synonym(s):

Coagulation factor

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.25

Pricing and availability is not currently available.

Quality Level

form

liquid

specific activity

50 units/mg protein (clotting assay)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

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This Item
233279233480219370
specific activity

50 units/mg protein (clotting assay)

specific activity

≥150 units/mg protein (clotting assay)

specific activity

≥170 units/mg protein (clotting assay)

specific activity

≥25,000 PEU/mg protein (clotting assay)

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

General description

Native coagulation factor α-XIIa from human plasma prepared from homogeneous Factor XII using dextran sulfate. Dextran sulfate is removed after activation. α-XIIa is a serine protease responsible for activation of Factor XI to Factor XIa. Factor XIIa and prekallikrein are thought to be involved in a reciprocal activation mechanism whereby Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to Factor XIIa.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.

Preparation Note

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Analysis Note

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma
homogeneous by SDS-PAGE

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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