1.41544

Parteck® MXP (Polyvinyl alcohol 3-82)

EMPROVE^® ESSENTIAL, Ph. Eur.

• Synonym(s): Parteck^® Polyvinyl alcohol, PVA, Polyvinyl alcohol
• Linear Formula: (C₂H₄O)_n
• CAS Number: 9002-89-5
• MDL number: MFCD00081922
• UNSPSC Code: 12352104

Properties

• Agency: Ph. Eur.
• Quality Level: 500
• product line: EMPROVE^® ESSENTIAL
• form: powder
• application(s): pharmaceutical; solid formulation; solubility enhancement
• storage temp.: 15-25°C
• InChI: 1S/C2H4O/c1-2-3/h2-3H,1H2
• InChI key: IMROMDMJAWUWLK-UHFFFAOYSA-N

Description

General description

With a lower degree of hydrolysis along the PVA chain, Parteck^® MXP 3-82 Polyvinyl alcohol is especially beneficial in forming strong interac­tions with hydrophobic drug molecules – in the solid state and in solution. Due to this, Parteck^® MXP 3-82 excipient has very high capabilities as a precipitation inhibitor and can maintain high levels of supersaturation for physiologi­cally relevant timescales. As a result, Parteck^® MXP 3-82 Polyvinyl alcohol can provide solubility enhancement for even the most challenging molecules.

Application

Parteck^® MXP 3-82 is a PVA-based excipient that is used in Hot Melt Extrusion for Solubility Enhancement in oral solid dosage forms.

Features and Benefits

• Superior supersaturation performance via precipitation inhibition
• High thermostability up to 250°C, extending the potential application range
• Stable high drug loads and suitability with a broad range of APIs
• Flexible release kinetics
• Compatible with several downstream processing capabilities, like direct compression, continuous manufacturing, thin film extrusion and 3D printing
• Optimized powder properties for excellent performance in the HME process
• Suitable polymer properties for HME, spray drying and 3D printing processes

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): No data available
• Flash Point(C): No data available