890701P
Avanti
14:0 EPC (Cl Salt)
Avanti Polar Lipids
Synonym(s):
1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
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About This Item
Empirical Formula (Hill Notation):
C38H77NO8PCl
CAS Number:
Molecular Weight:
742.45
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 10 mg (890701P-10mg)
pkg of 1 × 25 mg (890701P-25mg)
manufacturer/tradename
Avanti Polar Lipids
lipid type
transfection
cationic lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)OCC.[Cl-]
General description
1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC) is an acyl cationic lipid. O-alkyl phosphatidylcholines constitute the first chemically stable tri-esters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.
Application
1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC (Cl Salt)) is suitable for use in liposome formulations.
Biochem/physiol Actions
Synthetic cationic lipids serve as non-viral gene delivery agents. Change in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency. 1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC) aids in hydration during the formation of liposomes.
Packaging
5 mL Clear Glass Sealed Ampule (890701P-10mg)
5 mL Clear Glass Sealed Ampule (890701P-25mg)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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William P D Goldring et al.
Bioorganic & medicinal chemistry letters, 22(14), 4686-4692 (2012-06-19)
The synthesis and in vitro evaluation of four cationic lipid gene delivery vectors, characterized by acyclic or macrocyclic, and saturated or unsaturated hydrophobic regions, is described. The synthesis employed standard protocols, including ring-closing metathesis for macrocyclic lipid construction. All lipoplexes
Paria Parvizi et al.
International journal of pharmaceutics, 461(1-2), 145-156 (2013-12-04)
This study seeks correlations between the molecular structures of cationic and neutral lipids, the lipid phase behavior of the mixed-lipid lipoplexes they form with plasmid DNA, and the transfection efficacy of the lipoplexes. Synthetic cationic pyridinium lipids were co-formulated (1:1)
Emile Jubeli et al.
European journal of medicinal chemistry, 125, 225-232 (2016-09-24)
In this communication we describe the construction of four succinic-based cationic lipids, their formulation with plasmid DNA (pDNA), and an evaluation of their in vitro gene delivery into Chinese hamster ovarian (CHO-K1) cells. The cationic lipids employed in this work possess
Rumiana Koynova et al.
The journal of physical chemistry. B, 111(27), 7786-7795 (2007-06-19)
Some mixtures of two cationic lipids including phospholipid compounds (O-ethylphosphatidylcholines) as well as common, commercially available cationic lipids, such as dimethylammonium bromides and trimethylammonium propanes, deliver therapeutic DNA considerably more efficiently than do the separate molecules. In an effort to
Boris G Tenchov et al.
Biochimica et biophysica acta, 1778(10), 2405-2412 (2008-08-30)
Synthetic cationic lipids can be used as DNA carriers and are regarded to be the most promising non-viral gene carriers. For this investigation, six novel phosphatidylcholine (PC) cationic derivatives with various hydrophobic moieties were synthesized and their transfection efficiencies for
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