860842P

18:0(2R-OH) Sulfo GalCer

Avanti Research^™ - A Croda Brand 860842P, powder

• Synonym(s): 3-O-sulfo-D-galactosyl-β1-1′-N-[2"(R)-hydroxystearyl]-D-erythro-sphingosine (ammonium salt), (synthetic)
• Empirical Formula (Hill Notation): C₄₂H₈₄N₂O₁₂S
• CAS Number: 2260670-26-4
• Molecular Weight: 841.19
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 1 mg (860842P-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 860842P
• lipid type: sphingolipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC([C@H](O)CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H]([C@H]1CO)O.[NH4+]

Description

General description

18:0(2R-OH) Sulfo GalCer, also known as 3-O-sulfo-D-galactosyl-β1-1′-N-[2"(R)-hydroxystearyl]-D-erythro-sphingosine, is a sulfatide that belongs to the class of sphingolipids. It is highly found in membranous myelin sheath formed around nerve axons in gangliosides. This sulfated galactosylceramide contains 3-O-sulfo-β-d-galactose moiety linked to transmembrane-embedded unique ceramide containing 18C long chain base fatty acid (stearic acid) with 2′-hydroxyl group in R configuration.

Biochem/physiol Actions

Sulfatides are involved in various cellular processes such as protein trafficking, signal transduction and neuronal cell differentiation. Accumulation of sulfoglycolipids (mainly sulfo-galactosylceramide, S-GalCer) in lysosomes, due to the inherited deficiency of arylsulfatase A (ASA), causes metachromatic leukodystrophy in humans. In mice, deficiency of sulfatide causes paralysis due to demyelination.

Packaging

5 mL Amber Glass Screw Cap Vial (860842P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• Flash Point(F): No data available
• Flash Point(C): No data available