L134
Linopirdine
≥98% (HPLC)
Synonym(s):
1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one, DuP 996
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About This Item
Empirical Formula (Hill Notation):
C26H21N3O
CAS Number:
Molecular Weight:
391.46
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
≥98% (HPLC)
color
white to off-white
solubility
DMSO: >10 mg/mL
ethanol: 240 mg/mL
SMILES string
O=C1N(c2ccccc2)c3ccccc3C1(Cc4ccncc4)Cc5ccncc5
InChI
1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2
InChI key
YEJCDKJIEMIWRQ-UHFFFAOYSA-N
Gene Information
rat ... Kcnj1(24521)
General description
Linopiridine is a class of drugs that activates the nervous system and enhances the acetylcholine (Ach) in the brain. It can be prepared by reacting oxiindole with 4-picolyl chloride hydrochloride in the presence of a KF-Al2O3 catalyst.
Biochem/physiol Actions
Stimulates release of acetylcholine and other neurotransmitters; cognitive enhancer.
Legal Information
Sold under exclusive license from DuPont.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Chin-Wei Huang et al.
The international journal of neuropsychopharmacology, 11(5), 597-610 (2008-01-11)
Oxcarbazepine (OXC), one of the newer anti-epileptic drugs, has been demonstrating its efficacy on wide-spectrum neuropsychiatric disorders. However, the ionic mechanism of OXC actions in neurons remains incompletely understood. With the aid of patch-clamp technology, we first investigated the effects
Olga Zavaritskaya et al.
Hypertension (Dallas, Tex. : 1979), 61(1), 151-159 (2012-11-28)
KCNQ channels have been identified in arterial smooth muscle. However, their role in vasoregulation and chronic vascular diseases remains elusive. We tested the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral skeletal muscle arteries by perivascular adipose tissue
Motoharu Yoshida et al.
Journal of neurophysiology, 98(5), 2779-2794 (2007-08-31)
The M-current (current through Kv7 channels) is a low-threshold noninactivating potassium current that is suppressed by muscarinic agonists. Recent studies have shown its role in spike burst generation and intrinsic subthreshold theta resonance, both of which are important for memory
Alexander R Mackie et al.
The Journal of pharmacology and experimental therapeutics, 325(2), 475-483 (2008-02-15)
Pressor effects of the vasoconstrictor hormone arginine vasopressin (AVP), observed when systemic AVP concentrations are less than 100 pM, are important for the physiological maintenance of blood pressure, and they are also the basis for therapeutic use of vasopressin to
Richardson N Leão et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(42), 13353-13364 (2009-10-23)
While the synaptic mechanisms involved in the generation of in vitro network oscillations have been widely studied, little is known about the importance of voltage-gated currents during such activity. Here we study the role of the M-current (I(M)) in the
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