Skip to Content
Merck
All Photos(3)

Key Documents

View All Documentation

H8378

Sigma-Aldrich

D-α-Hydroxyglutaric acid disodium salt

≥95% (GC), cell analysisfor peptide synthesis

Synonym(s):

(R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Linear Formula:
C5H6O5Na2
CAS Number:
103404-90-6
Molecular Weight:
192.08
Beilstein:
5318041
MDL number:
MFCD00069573
UNSPSC Code:
12352106
PubChem Substance ID:
57654274
NACRES:
NA.22

product name

D-α-Hydroxyglutaric acid disodium salt, ≥95% (GC)

Quality Level

200

Assay

≥95% (GC)

form

powder

color

white to off-white

application(s)

cell analysis
peptide synthesis

storage temp.

−20°C

SMILES string

[Na].O[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1

InChI key

DZHFTEDSQFPDPP-HWYNEVGZSA-L

Looking for similar products? Visit Product Comparison Guide

Application

D-α-Hydroxyglutaric acid disodium salt can be used as a reagent in peptide synthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SLCG6529
SLBV3930
SLBP6935V
SLBD8946V
SLBC9418V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.
Liu Y, Gilbert MR, Kyprianou N, et al.
Acta Neuropathologica, 128(5), 723-732 (2014)
Ying Zhang et al.
Cancer research, 79(19), 4994-5007 (2019-08-09)
Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2, resulting in the production of the abnormal metabolite D-2 hydroxyglutarate. Here, we studied the effect of mutant IDH on cell proliferation and
Kancharana Bala Bhaskara Rao et al.
FEBS letters, 593(16), 2177-2193 (2019-06-19)
Isocitrate dehydrogenases (IDHs) are metabolic enzymes that are mutated in several cancers, resulting in overproduction of d-2-hydroxyglutarate (D-2HG). However, the signalling pathways and factors that regulate mutant IDHs or their metabolites remain elusive. Here, we report that in synchronized cells

Protocols

Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.

Chromatograms

application for HPLCapplication for HPLC

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service