937177

Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide

PEG average M_n 2000, PLLA average M_n 10000

• Synonym(s): Block copolymer, Drug delivery polymer, Polymeric micelles, Tissue engineering, Tumor imaging, mPEG-amine2k -PLL10k, mPEGNH₂-PLL
• Linear Formula: C₃H₉NO(OC₂H₄)_x-(C₆H₁₃N₂OBr)_n
• UNSPSC Code: 12162002
• NACRES: NA.21

Properties

• form: powder or chunks
• Quality Level: 100
• mol wt: PEG average M_n 2000; PLLA average M_n 10000
• color: white to off-white
• storage temp.: −20°C

Description

General description

Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications to improve therapeutic efficacy. The cationic PLL block can bind to DNA or RNA, as well as other therapeutic agents, while the amine-functionalized PEG block inhibits protein adsorption and can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.

Application

• Non-viral gene delivery applications
• Targeted drug delivery applications
• Protein coatings and tissue culture

Features and Benefits

• Self-assemble capability to form micelles and polymersomes
• Amine functional group at the side chain enables further rapid functionalization
• Cationic poly(L-lysine) has excellent DNA and RNA condensation property
• Biodegradable, biocompatible and water soluble

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable