936596

1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride

≥95%

• Synonym(s): 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₂₀N₄O₄ · xHCl
• CAS Number: 2162120-73-0
• Molecular Weight: 344.37 (free base basis)
• MDL number: MFCD31730833
• UNSPSC Code: 12161600
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥95%
• form: powder or crystals
• color: light yellow to yellow
• storage temp.: 2-8°C
• SMILES string: Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCN)C3C2=O)CC1

Description

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. A basic building block for making protein degrader library.

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Other Notes

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable