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Key Documents

934240

Sigma-Aldrich

Pomalidomide acetic acid

≥95.0%

Synonym(s):

N-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]glycine

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About This Item

Empirical Formula (Hill Notation):
C15H13N3O6
CAS Number:
Molecular Weight:
331.28
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.21

ligand

pomalidomide

Quality Level

Assay

≥95.0%

form

powder or crystals

storage temp.

2-8°C

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Legal Information

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Repr. 2 - STOT RE 2

Target Organs

Blood

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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