930636

VH 032 amide-alkyl C₅-acid

≥95%

• Synonym(s): (S,R,S)-AHPC-CO-C₅-acid, (S,R,S)-AHPC-amido-C₅-acid, 6-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}hexanoic acid, L-Prolinamide, N-(6-carboxy-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl],methyl]-, (4R)-
• Empirical Formula (Hill Notation): C₂₉H₄₀N₄O₆S
• CAS Number: 2162120-87-6
• Molecular Weight: 572.72
• MDL number: MFCD32903593
• UNSPSC Code: 12352106
• NACRES: NA.21

Properties

• ligand: VH032
• Quality Level: 100
• Assay: ≥95%
• form: powder
• functional group: carboxylic acid
• storage temp.: 2-8°C
• SMILES string: C([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Description

Application

VH 032 amide-alkyl C₅-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable