902543
Propargyl-PEG4-acid
Synonym(s):
4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH2CO2H
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About This Item
Empirical Formula (Hill Notation):
C12H20O6
CAS Number:
Molecular Weight:
260.28
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
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form
liquid
reaction suitability
reagent type: linker
availability
available only in USA
refractive index
n/D 1.460
density
1.164 g/mL
functional group
alkyne
carboxylic acid
storage temp.
−20°C
SMILES string
OC(CCOCCOCCOCCOCC#C)=O
Related Categories
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
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Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
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Description
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Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Self-react. C
Storage Class Code
5.2 - Organic peroxides and self-reacting hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants.
Debabrata Bhunia et al.
Archiv der Pharmazie, 348(10), 689-703 (2015-09-04)
A Cu-mediated azide-alkyne click chemistry protocol was employed for the synthesis of a focused library of novel 1,2,3-triazolyl conjugates bearing various carbohydrate-steroid/triterpenoid entities. The immunogenicity of these compounds was examined initially by ex vivo assays. The lead compound 15g was
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