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Sigma-Aldrich

BRIJ® O20

average Mn ~1,150

Synonym(s):

Polyoxyethylene (20) oleyl ether

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About This Item

Linear Formula:
C18H35(OCH2CH2)nOH, n~20
CAS Number:
9004-98-2
Molecular Weight:
1149.53
MDL number:
MFCD00074369
UNSPSC Code:
12162002
NACRES:
NA.23

description

non-ionic

Quality Level

200

mol wt

average Mn ~1,150

technique(s)

cell culture | mammalian: suitable
protein quantification: suitable

mp

25-30 °C (lit.)

HLB

15

InChI

1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22-20-18-21/h9-10,21H,2-8,11-20H2,1H3/b10-9-

InChI key

KWVPFECTOKLOBL-KTKRTIGZSA-N

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General description

Brij® O20 is a non-ionic surfactant that has an 18 carbon tail with a single double bond and the head contains 20 ethylene oxide moieties. It is polyethoxylated fatty alcohol that is hydrophilic in nature.

Application

Brij® O20 has been used:
  • as a detergent in medium A to prepare single detergent micelle aggregates
  • along with phosphate buffer saline (PBS) solution as the receptor solution for terbinafine (TBF) for in vitro permeation studies of TBF-free base in porcine skin
  • as a detergent to isolate detergent-resistant membranes from the mouse brain and to determine the distribution of major mammalian brain gangliosides, GM1, GD1a, GD1b and GT1b

Legal Information

Brij is a registered trademark of Croda International PLC

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

>464.0 °F - Equilibrium method

Flash Point(C)

> 240 °C - Equilibrium method

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ8633
MKCN7796
MKCM0893
MKCK7684
MKCJ2542

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Pulkit Khatri et al.
Journal of pharmaceutical sciences, 107(8), 2198-2207 (2018-04-08)
The study aims to elucidate the mechanism and the role of the molecular structure of surfactants and lipids in the formation of oil-in-water (o/w) self-emulsified nanoemulsions (SENs). The hypothesis is that the overall change of Gibb's free energy (ΔGf) during
Jessica Phelps et al.
Colloids and surfaces. B, Biointerfaces, 87(2), 391-398 (2011-06-28)
In this study, fluid precursor formulations for subcutaneous injection and in situ formation of hexagonal phase gels upon water absorption were developed as a strategy to sustain the release of naltrexone, a drug used for treatment of drug addiction. Precursor
Ahmed S Zidan et al.
International journal of pharmaceutics, 332(1-2), 55-63 (2006-12-16)
Quality by design (QBD) refers to the achievement of certain predictable quality with desired and predetermined specifications. A very useful component of the QBD is the understanding of factors and their interaction effects by a desired set of experiments. The
Yash Kapoor et al.
International journal of pharmaceutics, 361(1-2), 222-229 (2008-06-26)
Cyclosporine A (CyA) is an immunosuppressant drug that is used for treating a variety of ocular diseases and disorders. CyA is commonly delivered via eye drops, which is highly inefficient due to a low bioavailability of less than 5%. The
R B Shah et al.
International journal of pharmaceutics, 341(1-2), 189-194 (2007-05-25)
In the present work, a novel application of ultrasonic measurements is detailed to characterize nano-emulsion formulations as a part of the overall Quality by Design (QbD) goal. Ultrasonic resonator technology (URT) was utilized to measure sound velocity and absorption of
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