Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

161691

Sigma-Aldrich

Bis(4-nitrophenyl) carbonate

≥99%, for peptide synthesis

Synonym(s):

4-Nitrophenyl carbonate

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Linear Formula:
(O2NC6H4O)2CO
CAS Number:
5070-13-3
Molecular Weight:
304.21
Beilstein:
1892897
EC Number:
225-775-4
MDL number:
MFCD00007322
UNSPSC Code:
12352108
PubChem Substance ID:
24849947
NACRES:
NA.22

product name

Bis(4-nitrophenyl) carbonate, ≥99%

Quality Level

200

Assay

≥99%

form

powder

reaction suitability

reaction type: Carbonylations

mp

136-139 °C (lit.)

application(s)

peptide synthesis

SMILES string

[O-][N+](=O)c1ccc(OC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1

InChI

1S/C13H8N2O7/c16-13(21-11-5-1-9(2-6-11)14(17)18)22-12-7-3-10(4-8-12)15(19)20/h1-8H

InChI key

ACBQROXDOHKANW-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Reagent for the preparation of activated 4-nitrophenyl esters of N-protected amino acids.
Reagent for the synthesis of 4-nitrophenyl active esters of amino acids. Used in the preparation of symmetrical and unsymmetrical ureas.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCQ4487
MKCM4974
MKCK0546
MKCJ4938
MKBX3923V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

N,N′-Disuccinimidyl carbonate purum, ≥95.0% (NMR)

Sigma-Aldrich

43720

N,N′-Disuccinimidyl carbonate

G Cavallaro et al.
Nanomedicine (London, England), 4(3), 291-303 (2009-04-01)
To prepare new copolymers, useful for gene delivery, based on alpha, beta-poly-(N-2-hydroxyethyl)-D, L-aspartamide (PHEA) as a polymeric backbone and bearing an oligoamine such as diethylenetriamine in the side chain. Moreover, in order to reduce solvent volume and make the reaction
Maria-Cristina Turoczi et al.
Molecules (Basel, Switzerland), 13(12), 3192-3197 (2008-12-17)
A general method for the preparation of bis-ureas from bis(o-nitrophenyl) carbonate has been developed. Directional urea synthesis is achieved by sequential amine addition to bis(o-nitrophenyl) carbonate in two steps: in the first step bis(o-nitrophenyl) carbonate is reacted with benzylamine to
Lei Jiang et al.
Molecular pharmaceutics, 11(11), 3885-3892 (2014-04-11)
A divalent knottin containing two separate integrin binding epitopes (RGD) in the adjacent loops, 3-4A, was recently developed and reported in our previous publication. In the current study, 3-4A was radiofluorinated with a 4-nitrophenyl 2-(18)F-fluoropropinate ((18)F-NFP) group and the resulting
C Sardo et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 75, 60-71 (2015-04-08)
Small interfering RNAs (siRNAs) have the potential to be of therapeutic value for many human diseases. So far, however, a serious obstacle to their therapeutic use is represented by the absence of appropriate delivery systems able to protect them from
C Scialabba et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 695-705 (2014-10-05)
This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service