107425
Nicotinic hydrazide
97%
Synonym(s):
Nicotinic acid hydrazide
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About This Item
Empirical Formula (Hill Notation):
C6H7N3O
CAS Number:
Molecular Weight:
137.14
Beilstein:
119299
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
97%
mp
159-161 °C (lit.)
solubility
H2O: soluble 50 mg/mL
SMILES string
NNC(=O)c1cccnc1
InChI
1S/C6H7N3O/c7-9-6(10)5-2-1-3-8-4-5/h1-4H,7H2,(H,9,10)
InChI key
KFUSANSHCADHNJ-UHFFFAOYSA-N
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General description
Nicotinic hydrazide is a heterocyclic compound that can be used to synthesize Schiff bases.
Application
Nicotinic hydrazide was used in hydrazone library formation. It was used to study the oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase.
Biochem/physiol Actions
Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity.
Preparation Note
Nicotinic hydrazide dissolves in water at a concentration of 50 mg/ml to form a clear, colourless solution.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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V Goral et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(4), 1347-1352 (2001-02-15)
Dynamic combinatorial libraries are mixtures of compounds that exist in a dynamic equilibrium and can be driven to compositional self adaptation via selective binding of a specific assembly of certain components to a molecular target. We present here an extension
Thermo-chemical behavior of solid nicotinic hydrazide metal complexes in correlation with their stoichiometry.
Sekkina MM and El-Azm MG.
Thermochimica Acta, 77(1), 211-218 (1984)
H A Shoeb et al.
Antimicrobial agents and chemotherapy, 27(3), 399-403 (1985-03-01)
Oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase at the expense of H2O2 yielded reactive species which were able to reduce nitroblue tetrazolium and bleach p-nitrosodimethylaniline. Nicotinic acid hydrazide oxidation did not cause these effects. At slightly alkaline pH
Alireza Moradi et al.
Archiv der Pharmazie, 343(9), 509-518 (2010-09-02)
A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or anti-inflammatory activity in
[Tautomerism of 2-hydrazino-4-phenylthiazole<-->4-phenylthiazol-2-one hydrazone. Derivatives of acids. II. (4-phenyl-3-R-thiazol-2-ylidene) and beta-methyl-beta-(4-phenylthiazol-2-yl) hydrazides of picolinic, nicotinic, and isonicotinic acid].
L Bielak et al.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 44, 41-51 (1989-01-01)
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