- Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.
Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.
Natural product reports (2013-10-25)
Gwilherm Evano, Cédric Theunissen, Alexandre Pradal
PMID24154547
ABSTRACT
Copper-catalyzed Ullmann-Goldberg-type cross-coupling reactions have undergone nothing short of a renaissance over the last decade and an impressive number of procedures are now available for the formation of C-N, C-O and C-S bonds with remarkable efficiencies and surgical precision. These reactions have been recently integrated into natural product synthesis, which clearly resulted in the emergence of new retrosynthetic paradigms and bond disconnections. The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed in this article with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies.
MATERIALS
Product Number
Brand
Product Description
Copper, IRMM®, certified reference material, 0.5 mm wire
Copper, IRMM®, certified reference material, 0.1 mm foil
Copper - O.F.H.C., tube, 500mm, outside diameter 2.54mm, inside diameter 1.54mm, wall thickness 0.5mm, 99.95+%
Copper - O.F.H.C., rod, 100mm, diameter 25.4mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 200mm, outside diameter 1.78mm, inside diameter 0.8mm, wall thickness 0.49mm, 99.95+%
Copper - O.F.H.C., tube, 1000mm, outside diameter 9.5mm, inside diameter 7.9mm, wall thickness 0.8mm, 99.95+%
Copper - O.F.H.C., rod, 200mm, diameter 3.15mm, as drawn, 99.95+%
Copper, rod, 1000mm, diameter 2.0mm, as drawn, 99.99+%
Copper, rod, 200mm, diameter 5.0mm, as drawn, 99.999%
Copper, rod, 100mm, diameter 12.7mm, as drawn, 99.99+%
Copper, rod, 100mm, diameter 4.8mm, as drawn, 99.99+%
Copper, rod, 500mm, diameter 6.35mm, as drawn, 99.999%
Copper, rod, 200mm, diameter 6.35mm, as drawn, 99.999%
Copper, rod, 500mm, diameter 8.0mm, as drawn, 99.99+%
Copper, sphere, 100pcs, diameter 1.0mm, precision sphere grade 200
Copper, rod, 1000mm, diameter 4.8mm, hard, 99.9%
Copper, tube, 1000mm, outside diameter 3.0mm, inside diameter 1.2mm, wall thickness 0.9mm, as drawn, 99.9%
Copper, rod, 1000mm, diameter 9.5mm, hard, 99.9%
Copper, tube, 100mm, outside diameter 0.95mm, inside diameter 0.29mm, wall thickness 0.33mm, as drawn, 99.9%
Copper, rod, 500mm, diameter 9.5mm, hard, 99.9%
Copper, microfoil, disks, 25mm, thinness 0.1μm, specific density 86.2μg/cm2, permanent mylar 3.5μm support, 99.99+%
Copper, insulated wire, 20m, conductor diameter 0.05mm, insulation thickness 0.002mm, 2 micron polyesterimide insulation, 99.9%
Copper, insulated wire, 20m, conductor diameter 0.7mm, insulation thickness 0.01mm, polyurethane insulation
Copper, insulated wire, 1m, conductor diameter 0.1mm, insulation thickness 0.01mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Copper, insulated wire, 10m, conductor diameter 0.7mm, insulation thickness 0.01mm, polyurethane insulation
Copper, rod, 1000mm, diameter 4.8mm, as drawn, 99.99+%
Copper, rod, 100mm, diameter 2.0mm, as drawn, 99.99+%
Copper, rod, 500mm, diameter 4.8mm, as drawn, 99.99+%
Copper, rod, 100mm, diameter 5.0mm, as drawn, 99.999%
Copper, insulated wire, 5m, conductor diameter 0.05mm, insulation thickness 0.002mm, 2 micron polyesterimide insulation, 99.9%