SNCA
synuclein, alpha (non A4 component of amyloid precursor)
Synonyms:
NACP, PARK1, PARK4, PD1
Species:
Human SNCA (6622), Mouse Snca (20617), Rat Snca (29219), chicken SNCA (395393), Horse SNCA (100053270), domestic cat SNCA (101091694), dog SNCA (478478), cow SNCA (282857), sheep SNCA (100294604), domestic guinea pig Snca (100725375)
UniProtKB ID:
Gene ID:
- Human(6622) Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
- Mouse(20617) synuclein, alpha
- Rat(29219) synuclein, alpha (non A4 component of amyloid precursor)
- chicken(395393) synuclein, alpha (non A4 component of amyloid precursor)
- Horse(100053270) synuclein, alpha (non A4 component of amyloid precursor)
- domestic cat(101091694) synuclein, alpha (non A4 component of amyloid precursor)
- dog(478478) synuclein, alpha (non A4 component of amyloid precursor)
- cow(282857) synuclein, alpha (non A4 component of amyloid precursor)
- sheep(100294604) synuclein, alpha (non A4 component of amyloid precursor)
- domestic guinea pig(100725375) synuclein, alpha (non A4 component of amyloid precursor)
- naked mole-rat(101700039) synuclein, alpha (non A4 component of amyloid precursor)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-α-synuclein (Ser129) Antibody, clone PS129, ,
Species Reactivity
bovine, human, mouse, porcine, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-Synuclein-α (pTyr136) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-phospho-SNCA (pSer129) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Synuclein α Antibody, Chemicon®, from sheep,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
western blot
Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14, clone nSyn14, Upstate®, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
α-Synuclein E46K human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Species
human
α-Synuclein A53T human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Species
human