LATS1
large tumor suppressor kinase 1
Synonyms:
WARTS, wts
Species:
Human LATS1 (9113), Mouse Lats1 (16798), Rat Lats1 (308265), sheep LATS1 (101122867), Domestic Rabbit LATS1 (100341222), domestic guinea pig Lats1 (100716806), naked mole-rat Lats1 (101725200), Zebrafish lats1 (553164), chicken LATS1 (421627), cow LATS1 (535935) ...More
UniProtKB ID:
Gene ID:
- Human(9113) Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]
- Mouse(16798) large tumor suppressor
- Rat(308265) large tumor suppressor kinase 1
- sheep(101122867) LATS, large tumor suppressor, homolog 1 (Drosophila)
- Domestic Rabbit(100341222) LATS, large tumor suppressor, homolog 1 (Drosophila)
- domestic guinea pig(100716806) large tumor suppressor kinase 1
- naked mole-rat(101725200) large tumor suppressor kinase 1
- Zebrafish(553164) LATS, large tumor suppressor, homolog 1 (Drosophila)
- chicken(421627) LATS, large tumor suppressor, homolog 1 (Drosophila)
- cow(535935) LATS, large tumor suppressor, homolog 1 (Drosophila)
- Horse(100060397) LATS, large tumor suppressor, homolog 1 (Drosophila)
- domestic cat(101081470) LATS, large tumor suppressor, homolog 1 (Drosophila)
- dog(476241) LATS, large tumor suppressor, homolog 1 (Drosophila)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-p-LATS1 (Thr1079) Antibody, clone 2D2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
inhibition assay
western blot
inhibition assay
western blot
Anti-LATS1 (N-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-LATS1 antibody produced in mouse, clone 3A7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-LATS1 Antibody, clone 1D18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LATS1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
immunohistochemistry
Proteins
Product Number
Description
Species
LATS1, active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
esiRNA
Product Number
Description
Species