HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
Synonyms:
HNRPA1, HNRPA1L3, hnRNP A1, hnRNP-A1
Species:
Human HNRNPA1 (3178), Mouse Hnrnpa1 (15382), Rat Hnrnpa1 (29578), Zebrafish hnrnpa1 (378453), Horse HNRNPA1 (100034153), domestic cat HNRNPA1 (101092031), cow HNRNPA1 (505093), domestic guinea pig Hnrnpa1 (100726972), naked mole-rat Hnrnpa1 (101711324)
UniProtKB ID:
Gene ID:
- Human(3178) Summary: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008]
- Mouse(15382) heterogeneous nuclear ribonucleoprotein A1
- Rat(29578) heterogeneous nuclear ribonucleoprotein A1
- Zebrafish(378453) heterogeneous nuclear ribonucleoprotein A1
- Horse(100034153) heterogeneous nuclear ribonucleoprotein A1
- domestic cat(101092031) heterogeneous nuclear ribonucleoprotein A1
- cow(505093) heterogeneous nuclear ribonucleoprotein A1
- domestic guinea pig(100726972) heterogeneous nuclear ribonucleoprotein A1
- naked mole-rat(101711324) heterogeneous nuclear ribonucleoprotein A1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-hnRNP-A1 antibody, Mouse monoclonal, ~2 mg/mL, clone 4B10, purified from hybridoma cell culture,
Species Reactivity
bovine, canine, human
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
Anti-hnRNP A1 Antibody, clone 1I21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-HNRNPA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-HNRPA1 antibody produced in mouse, clone 2E6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-HNRNPA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot