CHRNA4
cholinergic receptor, nicotinic, alpha 4 (neuronal)
Synonyms:
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
Species:
Human CHRNA4 (1137), Mouse Chrna4 (11438), Rat Chrna4 (25590), sheep CHRNA4 (101118889), Domestic Rabbit CHRNA4 (100345481), domestic guinea pig Chrna4 (100716877), naked mole-rat Chrna4 (101714448), Zebrafish chrna4 (556619), domestic cat CHRNA4 (101101300), cow CHRNA4 (537251) ...More
UniProtKB ID:
Gene ID:
- Human(1137) Summary: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
- Mouse(11438) cholinergic receptor, nicotinic, alpha polypeptide 4
- Rat(25590) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- sheep(101118889) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- Domestic Rabbit(100345481) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- domestic guinea pig(100716877) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- naked mole-rat(101714448) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- Zebrafish(556619) cholinergic receptor, nicotinic, alpha 4
- domestic cat(101101300) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- cow(537251) cholinergic receptor, nicotinic, alpha 4
- Horse(100146784) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- dog(485972) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- chicken(395606) cholinergic receptor, nicotinic, alpha 4
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Small Molecule - Agonist
Product Number
Description
Species
S(−)-Nicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
(−)-Nicotine hemisulfate salt, ≥95% (TLC), ~35 % (w/v) in H2O (based on free base),
Species
human
Small Molecule - Antagonist
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Nicotinic Acetylcholine Receptor α4 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-CHRNA4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot