CACNB4
calcium channel, voltage-dependent, beta 4 subunit
Synonyms:
CAB4, CACNLB4, EA5, EIG9, EJM, EJM4, EJM6
Species:
Human CACNB4 (785), Mouse Cacnb4 (12298), Rat Cacnb4 (58942), chicken CACNB4 (374259), domestic cat CACNB4 (101101576), cow CACNB4 (282161), Horse CACNB4 (100057916), dog CACNB4 (609361), sheep CACNB4 (101117907), domestic guinea pig Cacnb4 (100723776)
UniProtKB ID:
Gene ID:
- Human(785) Summary: This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
- Mouse(12298) calcium channel, voltage-dependent, beta 4 subunit
- Rat(58942) calcium channel, voltage-dependent, beta 4 subunit
- chicken(374259) calcium channel, voltage-dependent, beta 4 subunit
- domestic cat(101101576) calcium channel, voltage-dependent, beta 4 subunit
- cow(282161) calcium channel, voltage-dependent, beta 4 subunit
- Horse(100057916) calcium channel, voltage-dependent, beta 4 subunit
- dog(609361) calcium channel, voltage-dependent, beta 4 subunit
- sheep(101117907) calcium channel, voltage-dependent, beta 4 subunit
- domestic guinea pig(100723776) calcium channel, voltage-dependent, beta 4 subunit
- naked mole-rat(101723713) calcium channel, voltage-dependent, beta 4 subunit
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Small Molecule - Allosteric Modulator
Product Number
Description
Species
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CACNB4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-CACNB4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-CACNB4, C-Terminal antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, pig, rat
Application
ELISA
western blot
western blot
Anti-CACNB4 (Internal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot
western blot
Small Molecule - Blocker
Product Number
Description
Species
esiRNA
Product Number
Description
Species