SRP6322
BMP8B human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
BMP8, Bone morphogenetic protein 8B, OP2
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
liquid
mol wt
18.1 kDa (162 aa, 264-402 aa + His tag)
packaging
pkg of 100 μg
concentration
1 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... BMP8B(656)
General description
The BMP8B (bone morphogenetic protein 8b) gene is mapped to human chromosome 1p34.2. It is also expressed in testis germ cell.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-β (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. Recombinant human BMP8B protein, fused to His-tag at N-terminus, was expressed in E.coli.
Biochem/physiol Actions
The BMP8B (bone morphogenetic protein 8b) gene expression prevents cancer cell proliferation and activates cell death. Decreased gene expression is observed in pancreatic cancer. BMP8B mediates the process of placentation, by regulating cell division, differentiation and survival. It prevents glucocorticoid-induced bone cell death.
Physical form
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Genetic variants in BMP8B gene are associated with growth traits in Chinese native cattle
Cao XK, et al.
Gene, 532(1), 115-120 (2013)
Developmental dysplasia of the hip: linkage mapping and whole exome sequencing identify a shared variant in CX3CR1 in all affected members of a large multigeneration family
Feldman GJ, et al.
Journal of Bone and Mineral Research, 28(12), 2540-2549 (2013)
Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development
Zhao GQ and Hogan BLM
Mechanisms of Development, 57(2), 159-168 (1996)
Andrew J Whittle et al.
Cell, 149(4), 871-885 (2012-05-15)
Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and, here, we describe a role for BMP8B in the direct regulation of thermogenesis. BMP8B is induced
Zhuoxin Cheng et al.
Oncology reports, 32(5), 1861-1866 (2014-09-02)
Pancreatic cancer has become one of the most common types of cancer. It is believed that inhibiting the apoptosis of tumor cells as well as overgrowth of tumor cells accelerate the progression and development of cancer. However, the detailed mechanisms
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