SAB5500186

Anti-Thymidylate Synthase antibody, Rabbit monoclonal

clone SP112, recombinant, expressed in proprietary host, affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41
• conjugate: unconjugated
• application: IHC
• clone: SP112, monoclonal
• species reactivity: human (tested)
• technique(s): immunohistochemistry: 1:100

Properties

• biological source: rabbit
• recombinant: expressed in proprietary host
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: SP112, monoclonal
• species reactivity: human (tested)
• species reactivity (predicted by homology): rabbit, mouse, frog, bovine, rat
• technique(s): immunohistochemistry: 1:100
• isotype: IgG
• UniProt accession no.: P04818
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... TYMS(7298)

Description

General description

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma.

Immunogen

Synthetic peptide near C-terminus of human TS.

Features and Benefits

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Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable