SAB4700486

Monoclonal Anti-CD138, azide free antibody produced in mouse

clone B-A38, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-SDC1, Anti-Syndecan 1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: B-A38, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): flow cytometry: suitable
• isotype: IgG1
• NCBI accession no.: NM_001006946.1
• UniProt accession no.: P18827
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... SDC1(6382)

Description

General description

Cluster of differentiation 138 (CD138), also known as syndecan 1, is a cell surface heparan sulfate proteoglycan. It is encoded by the gene mapped to human chromosome 2p21-p25. The encoded protein belongs to SDC family and is exclusively expressed on epithelial cells. Members of SDC protein family contain an extracellular domain carrying heparan sulfate, a transmembrane domain and a cytoplasmic domain.

The antibody B-A38 recognizes CD138 (syndecan 1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.

Immunogen

U266 human peripheral blood myeloma cell line

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 3-5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cluster of differentiation 138 (CD138) along with α2β1 integrin binds to collagen I and regulates cell motility. The encoded protein functions as a coreceptor for variety of biological factors such as, growth factors, angiogenic factors, cytokines and chemokines. CD138 acts as a potential marker for putative circulating CD15⁺/CD30⁺ cells in poor outcome Hodgkin lymphoma patients. Genetic variations in the gene is associated with the development of breast cancer. Thus, CD138 can be considered as a potential therapeutic target for inflammatory breast cancer (IBC).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable