SAB4504327

Anti-phospho-Werner Syndrome Helicase (pSer¹¹⁴¹) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): RECQ3, RECQL2, WRN
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 162 kDa
• species reactivity: human, rat, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; western blot: 1:500-1:1000
• NCBI accession no.: Q14191
• UniProt accession no.: Q14191
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer1141)
• Gene Information: human ... WRN(7486)

Description

General description

Werner syndrome, RecQ helicase-like (WRN) protein belongs to the RecQ family of DNA helicases. It has an adenosine triphosphate (ATP) binding site, one DExH helicase box, one exonuclease domain, and a nuclear localization signal. It is predominantly located in the nucleus. The WRN gene is located on human chromosome 8p12.

Immunogen

The antiserum was produced against synthesized peptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141.

Immunogen Range: 1107-1156

Biochem/physiol Actions

Werner syndrome, RecQ helicase-like (WRN) can interact with DNA polymerase δ (POLD1) and replication protein A (RPA) that are essential for the replication and repair of DNA. It also interacts with Ku protein which participates in double-strand DNA break repair. Mutation of the WRN gene results in Werner syndrome. WRN is a mortal target for cancer cells with microsatellite instability (MSI).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable