SAB4502560
Anti-RAC1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Cell migration-inducing gene 5 protein, RAC1, Ras-like protein TC25, Ras-related C3 botulinum toxin substrate 1, p21-Rac1
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About This Item
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biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 21 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RAC1(5879)
Related Categories
General description
The gene ras-related C3 botulinum toxin substrate 1 (RAC1), with 7 exons spanning 29 kb, is mapped to human chromosome 7p22. The encoded protein belongs to the Rho family of small GTPases. RAC1 is a maternal factor expressed in decidual cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human Rac1/CDC42.
Immunogen Range: 38-87
Immunogen Range: 38-87
Biochem/physiol Actions
Ras-related C3 botulinum toxin substrate 1 (RAC1), expressed in decidua, modulates uterine secretions that helps in maternal-fetal communication crucial for placental development and establishment of pregnancy. RAC1 regulates the secretory activity of human endometrial stromal cells during decidualization. Members of rho family of small GTPases, including RAC1, is associated with signal transduction pathways that regulate proliferation, adhesion, and migration of cells during embryonic development and invasiveness of tumor cells. RAC1 acts as a regulator of nuclear factor-κB (NF-κB) signaling pathway, and it is also associated with inflammation.Hindrance of RAC1 expression in lens epithelial cells can be a potential method for the treatment of cataract. Elevated expression of RAC1 promotes the proliferation, migration, and invasion of lens epithelial cells, and regulates the epithelial-mesenchymal transition (EMT) process, thus, RAC1 is associated with cataract. RAC1 functions as an oncogene in tumor cells. Deletion of RAC1 retards cell migration and wound healing of epidermal keratinocytes.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Small GTPase Rac1: structure, localization, and expression of the human gene.
Matos P, et al.
Biochemical and Biophysical Research Communications, 277(3), 741-751 (2000)
Rac1 Regulates Endometrial Secretory Function to Control Placental Development.
Davila J, et al.
PLoS Genetics, 11(8), e1005458-e1005458 (2015)
RAC1 overexpression promotes the proliferation, migration and epithelial-mesenchymal transition of lens epithelial cells.
Su J and Li H
International Journal of Clinical and Experimental Pathology, 8(9), 10760-10767 (2015)
Seung Hee Lee et al.
International journal of molecular sciences, 21(16) (2020-08-23)
Increased platelet activation and apoptosis are characteristic of diabetic (DM) platelets, where a Parkin-dependent mitophagy serves a major endogenous protective role. We now demonstrate that Parkin is highly expressed in both healthy platelets and diabetic platelets, compared to other mitochondria-enriched
Victoria J Mar et al.
Pigment cell & melanoma research, 27(6), 1117-1125 (2014-07-22)
Activating mutations in the GTPase RAC1 are a recurrent event in cutaneous melanoma. We investigated the clinical and pathological associations of RAC1(P29S) in a cohort of 814 primary cutaneous melanomas with known BRAF and NRAS mutation status. The RAC1(P29S) mutation
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