SAB4200610

Monoclonal Anti-EXOSC5 antibody produced in mouse

~1.0 mg/mL, clone EXOSC5(A)-2, purified immunoglobulin

• Synonym(s): Anti-RRP41B, Anti-RRP46, Anti-Rrp46p, Anti-chronic myelogenous leukemia tumor antigen 28, Anti-exosome complex component RRP46, Anti-exosome complex exonuclease RRP46, Anti-exosome component 5, Anti-exosome component Rrp46, Anti-hRrp46p, Anti-p12B, Anti-ribosomal RNA-processing protein 46
• UNSPSC Code: 12352203

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: EXOSC5(A)-2, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~25 kDa
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): immunoblotting: 2-5 μg/mL using whole extracts of human HEK-293T cells; immunofluorescence: 2-5 μg/mL using human HeLa cells.
• isotype: IgG1
• UniProt accession no.: Q9NQT4
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... EXOSC5(56915)

Description

General description

Monoclonal Anti-EXOSC5 (mouse IgG1 isotype) is derived from the hybridoma EXOSC5(A)-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the N-terminal region of human EXOSC5, conjugated to KLH. Exosome component 5 (EXOSC5) also known as exosome complex component RRP46, is a part of the eukaryotic RNA exosome which is non-catalytic. It is located on the human chromosome at 19q13.2.

Immunogen

synthetic peptide corresponding to the N-terminal region of human EXOSC5, conjugated to KLH. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

Application

Monoclonal Anti-EXOSC5 antibody has been used in

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

Exosome component 5 (EXOSC5) plays a role in RNA processing anddegrading a target RNA. It has a 3′-5′exoribonuclease activity. It is over expressed in various forms of cancer including lung, prostrate, melanoma and colorectal cancer.

Physical form

solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable