PZ0280

CP-456773 sodium salt

≥98% (HPLC), powder, IL-1β secretion inhibitor

• Synonym(s): CRID3, Cytokine release inhibitory drug 3, MCC950, N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
• Empirical Formula (Hill Notation): C₂₀H₂₃N₂NaO₅S
• CAS Number: 256373-96-3
• Molecular Weight: 426.46
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823808
• NACRES: NA.77

Properties

• product name: CP-456773 sodium salt, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: CC(O)(C)C1=COC(S([N-]C(NC2=C(CCC3)C3=CC4=C2CCC4)=O)(=O)=O)=C1.[Na+]
• InChI: 1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
• InChI key: LFQQNXFKPNZRFT-UHFFFAOYSA-M

Description

Application

CP-456773 sodium salt has been used :

• In in vivo experiments to study the neuroprotective action of ketogenic diet.
• To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.
• To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.

Biochem/physiol Actions

CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1α and IL-18. It is also referred to as MCC950.

CP-456773 sodium salt (CRID3) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome. CP-456773 sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable