P8727

Palmityl trifluoromethyl ketone

phosholipase A2 inhibitor

• Synonym(s): PACOCF3, Pentadecyl trifluoromethyl ketone
• Empirical Formula (Hill Notation): C₁₇H₃₁F₃O
• CAS Number: 141022-99-3
• Molecular Weight: 308.42
• MDL number: MFCD00797669
• UNSPSC Code: 12352202
• PubChem Substance ID: 329820334
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Assay: ≥98% (TLC)
• form: liquid
• concentration: 10 mg/mL in ethanol
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCCC(=O)C(F)(F)F
• InChI: 1S/C17H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(21)17(18,19)20/h2-15H2,1H3
• InChI key: MAHYXYTYTLCTQD-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Reversible inhibitor of calcium-dependent phospholipase A₂ (IC₅₀ = 3.8 μM). Unlike other PLA2 inhibitors studied, PACOCF3 at 50 μM induced an increase in intracellular [Ca²⁺], and at 10 μM, enhanced calcium-ion influx induced by ATP and bradykinin.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H319
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 57.2 °F - closed cup
• Flash Point(C): 14.0 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves