O2375
L-Ornithine monohydrochloride
≥99%
Synonym(s):
(S)-2,5-Diaminopentanoic acid monohydrochloride
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About This Item
Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
Molecular Weight:
168.62
Beilstein:
3625847
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
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Product Name
L-Ornithine monohydrochloride, ≥99%
Quality Level
Assay
≥99%
form
powder
impurities
ammonia and citrulline, essentially free
color
white
application(s)
cell analysis
SMILES string
Cl.NCCC[C@H](N)C(O)=O
InChI
1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
InChI key
GGTYBZJRPHEQDG-WCCKRBBISA-N
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Application
L-Ornithine monohydrochloride has been used to study the blocking effect of L-ornithine on the transport system that carries L-arginine for the overproduction of nitric oxide during lipopolysaccharide induced endotoxemia in rat model. It has also been used in decarboxylation test of amino acids.
Biochem/physiol Actions
L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle. In mammals, ornithine serves as a precursor for polyamines and proline biosynthesis. Spermine synthesized from ornithine, is an abundant polyamine observed in tumors such as breast carcinomas. Administration of L-ornithine is known to improve subjective index of sleep quality. L-ornithine reduces the cortisol/DHEA-S (dehydroepiandrosterone) ratio, that is associated with stress. In mice, L-ornithine is found to affect the levels of plasma growth hormone, corticosterone and melatonin levels in mice.
Other Notes
Product of arginine degradation by arginase
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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THE EFFECT OF L-ORNITHINE ON THE INNER EAR OF RATS IN THE LIPOPOLYSACCHARIDE INDUCED ENDOTOXEMIA MODEL
Keal Gorur
Kulak Burun bo?az Ihtisas Dergisi : KBB = Journal of Ear, Nose, and Throat (2018)
Identification of bacteria potentially producing biogenic amines isolated from Venezuelan white cheese
Alba Lorena BENAVIDES Sierra
Revista Brasileira de Farmacognosia (2016)
L-Ornithine affects peripheral clock gene expression in mice
Takafumi Fukuda
Scientific Reports (2016)
Arginase Activity in Human Breast Cancer Cell Lines: N?-Hydroxy-l-arginine Selectively Inhibits Cell Proliferation and Induces Apoptosis in MDA-MB-468 Cells
Rajan Singh
Cancer Research, 60(12) (2000)
Sherry Dadsetan et al.
Biochemical pharmacology, 85(1), 115-123 (2012-10-30)
Combined administration of ornithine and phenylacetate (OP) is proposed as a novel treatment of hyperammonemia and hepatic encephalopathy. Ornithine is believed to increase ammonia fixation into glutamine in muscle tissue and glutamine is subsequently thought to react with phenylacetate forming
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